During the pathology diagnostic process, CD38 antigen can also be found as a marker of differentiation, especially into plasma cells, in malignancies, such as lymphoplasmacytic lymphoma (Waldenström macroglobulinemia), MYC translocated aggressive B-cell lymphomas, ALK-positive large B-cell lymphoma, high-grade B-cell lymphoma (HGBL; including HGBL with rearrangement of MYC, BCL2, BCL6 genes), plasmablastic lymphoma, plasmablastic plasma cell myeloma, anaplastic large cell lymphoma, and primary effusion diffused large B-cell lymphoma [143,144,145,146,147]. Here, BCL2 is linked to high grade B-cell lymphoma.