Besides, a recent phase 3 trial evaluating azacitidine with or without ivosidenib in IDH1-mutant newly diagnosed AML unfit for intensive treatment showed a 12-month event-free survival rate significantly higher in the experimental group, along with a benefit in OS (24.0 vs. 7.9 months; p = 0.001), opening new therapeutic opportunities in such a setting. The gene discussed is IDH1; the disease is acute myeloid leukemia.