In addition, the overall base variation layout at the whole-exon level in the MPP component as a whole was more consistent with the SBS13 profile in the Catalogue of Somatic Mutations in Cancer (COSMIC), suggesting an association with the activation of AID/APOBEC cytidine deaminase in cancer [24] (Figure 2F,G), while both fractions exhibited base features associated with DNA mismatch repair defects, including SBS15 and SBS6 [25]. Here, CDA is linked to cancer.