Because the promoter region of miR-129-2 can be persistently hyper-methylated, leading to transcriptional inhibition in other cancer types [37], we tested whether the regulatory effects of SNHG1 on miR-129-2 could be mediated by a differentially methylated region (DMR) within the miR-129-2 promoter in MIBC cells. Here, SNHG1 is linked to cancer.