BRCA2 and neoplasm: In support of these findings, Jenzer and colleagues found that, although tumors with a loss of BRCA2 showed increased levels of tumor-infiltrating lymphocytes (TILs), the ratio of cytotoxic CD8+ T lymphocytes to immunosuppressive T regulatory CD25+ FOXP3+ lymphocytes was lower compared to BRCA2 wild-type tumors [113].