ERBB2 and non-small cell lung carcinoma: The prognostic value of HER2 amplification is unclear, although one observational study in resected NSCLC found that high levels of HER2 amplification (defined as HER2/CEP17 ratio ≥ 5 or copy number ≥ 10) in resected NSCLC were associated with shorter overall and disease-free survival compared to lower levels [9].