Probable mechanisms by which ASCs might increase the metastatic capacity of breast cancer cells include initiation of EMT, matrix degradation through elevated expression of MMPs, induction of angiogenesis, and secretion of paracrine factors favoring metastatic spread [51], PDGF-D [53], IL-6 [58], and IL-8 [52]. Here, CXCL8 is linked to breast carcinoma.