Recently it was suggested that increased levels of leptin secreted by obesity altered adipose stem cells induced the EMT and CSC reprogramming of MCF7, BT20, HCC1806, and TU-BcX cancerous cells through expression of Serpine1, SNAI2, IL6, TWIST1, and PTGS2. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.