We observed significant enrichments for DEGs identified in our analysis of colon organoids of FAP versus healthy subjects with those seen in FAP CRC tumors versus NAT (as expected), TCGA-EOCRC and TCGA-60+, which support our use of the FAP colon organoid system to model early events preceding EOCRC development. Here, BRD2 is linked to Familial adenomatous polyposis.