Cre-mediated recombination in a second mouse strain, R26-tdTomato ApccKO/cKO Lgr5-EGFP-CreERT2, resulted in the knockout of the Apc gene in IESCs, accompanied by the production of the red fluorescent protein tdTomato in growing adenomas (Figure 4B, right part of the diagram). This evidence concerns the gene LGR5 and adenoma.