Moreover, tdTomato-positive cells in the adenomas of R26-tdTomato ApccKO/cKO Lgr5-EGFP-CreERT2 showed a significant upregulation of Wnt target genes compared with tdTomato-negative cells [73,74,75,76]—also see the webpage https://web.stanford.edu/group/nusselab/cgi-bin/wnt/target_genes (accessed on 1 February 2022). Here, LGR5 is linked to adenoma.