Since, in most lineages derived from CRC, a number of genes are regulated by YAP-β-catenin-T-box 5 (TBX5) complexes [115], there is a possibility that a decrease in β-catenin levels increases the amount of free YAP protein in the cell, which in turn leads to an increased expression of genes regulated by this transcriptional regulator in complex with TEAD factors. The gene discussed is YAP1; the disease is colorectal carcinoma.