ETV6 invalidations are, however, known in leukemia: somatic mutations of ETV6 remain rare in AML [28], but germline mutations are also possible in the context of thrombocytopenia predisposing to AML, Myelodysplastic Syndromes (MDS), Chronic MyeloMonocytic Leukemia (CMML), B-ALL, or multiple myeloma [1]. This evidence concerns the gene ETV6 and precursor B-cell acute lymphoblastic leukemia.