Xiao et al. showed that leukemic blasts upregulated IFN-driven pDC transcriptional programs, particularly IRF7, MX1, and IFI35, directing toward pDC differentiation and expansion in the case of pDC-AML, but also in AML with the RUNX1 mutation, even in the absence of pDC [102]. This evidence concerns the gene MX1 and acute myeloid leukemia.