ETV6 (TEL) is frequently mutated or deleted [8,12,15,16,17,24], contrasting with classical defects in other leukemia where translocations are more frequent, including t(12;21)(p13;q22) ETV6::RUNX1 in B-cell Acute Lymphoblastic Leukemia (B-ALL) [27], t(5;12)(q32;p13) ETV6::PDGFRB, t(9;12)(p24;p13) ETV6::JAK2 or t(4;12) (q12;p13) ETV6::PDGFRA in hypereosinophilic syndromes, and other translocations in rare cases of Acute Myeloid Leukemia (AML) [28]. The gene discussed is ETV6; the disease is B-cell acute lymphoblastic leukemia.