High expression of miR-145 decreased angiogenesis [51]; induced differentiation of macrophages by interleukin 6 (IL-6) [52]; silenced the stem cell self-renewal and pluripotency program by suppressing multiple pluripotent genes such as OCT4, SOX2, and KLF4 [53]; promoted the epithelial–mesenchymal transition by suppressing FGF10 [54]; and increased apoptosis in prostate cancer [55]. This evidence concerns the gene POU5F1 and Familial prostate cancer.