Specifically, miR-145-5p can negatively regulate multiple genes in the thyroid cancer signaling pathway (hsa05216, p = 0.031), including tropomyosin 3 (TPM3), neuroblastoma RAS proto-oncogenes (NRAS), catenin beta 1 (CTNNB1), MYC proto-oncogene, BHLH transcription factor (MYC), and cyclin D1 (CCND1). This evidence concerns the gene TPM3 and thyroid cancer.