The ER chaperone protein 78-kDa glucose-regulated protein (GRP78) is often elevated in a broad range of human cancers where it activates pro-survival pathways promoting tumor survival and proliferation, and confers resistance to routinely utilized chemotherapeutic agents (i.e., cisplatin, paclitaxel, doxorubicin), making it an attractive cancer target [9,10,11,12,13]. The gene discussed is HSPA5; the disease is cancer.