ESM1 and neoplasm: Previously, we discovered that endothelial cell-specific molecule-1 (ESM-1) is the most increased gene in radiotherapy-resistant (RT-R)-TNBC cells compared to their parental cells and determined that ESM-1 plays a critical role in the tumorigenesis of RT-R-TNBC cells through the regulation of several genes related to tumor growth, progression and metastasis.