In a previous study, we reported that, compared to MDA-MB-231 cells, RT-R-MDA-MB-231 cells secrete higher levels of ATP and adenosine [23], and ATP and adenosine promote tumor progression in TNBC cells and RT-R-TNBC cells through the activation of the P2Y2 receptor (P2Y2R) and A2A receptor (A2AR), respectively [23,24]. The gene discussed is ADORA2A; the disease is neoplasm.