Building upon recent reports [12,25,26,27], we thus embarked upon characterising the effects induced by MB-PDT (a clinically approved sensitizer) on ICD in NSCLC cells using low energy light sources and investigated the role of activated non-autologous CD8+ T cells on survival of MB-PDT-treated human lung cancer cells and patient-derived organoids in co-culture. This evidence concerns the gene CD8A and lung carcinoma.