TP53 and head and neck squamous cell carcinoma: Such examples are gallic acid (a metabolite produced by the microbiome in the gut that could help to incite intestinal cancers in APC mutant mice with mutations in Tp53 through the WNT pathway) [113], and butyrate (a short chain fatty acid produced by bacteria in the gut) which can cause growth inhibition and apoptosis in HNSCC cells [114,115] and regulate galectin-1 content in HNSCC cells (thus influencing morphologic changes, cellular interactions, and differentiation) [116].