Both MYCN and hypoxia-inducible factor 1α (HIF-1α) are required for sustaining the aerobic glycolysis phenotype in neuroblastoma cells by transcriptional upregulation of glycolytic enzymes, including hexokinase 2 (HK2) and lactate dehydrogenase A (LDHA) [64]. This evidence concerns the gene HK2 and neuroblastoma.