CMKLR1 and neoplasm: With regard to cancer, chemerin is thought to affect tumor development via three main mechanisms: (1) suppressing the tumor as a strong chemoattractant inducing immunocyte recruitment to the tumor, (2) promoting the tumor by activating endothelial angiogenesis, and (3) affecting the intracellular signaling of tumor cells via CMKLR1 and GPR1, resulting in context-dependent anti-tumoral or tumor-promoting actions (reviewed in [15]); [10,12,15,31,32,33].