IFI27 and cancer: However, the interferon response gene exhibiting the most prominent transcriptional induction upon chemerin treatment in all cell lines was IFI27 (coding for Interferon alpha-inducible protein 27), which was initially reported to mediate IFN-induced cell death, but recent studies demonstrated that IFI27 is also able to affect cell cycle regulation leading to inhibition of proliferation of cancer cells without apoptosis induction [62,63,64,65,66].