Finally, a 69-year-old man with AML transformation after CMML-2, FLT3-ITD, and an IDH2 mutation, who was not eligible for alloSCT, received three different treatments: azacytidine (achieving a partial response), sorafenib plus azacytidine (achieving sustained complete remission for 7 months), and gilteritinib (achieving sustained complete remission for 1 year). This evidence concerns the gene FLT3 and acute myeloid leukemia.