Finally, a 69-year-old man with AML transformation after CMML-2, FLT3-ITD, and an IDH2 mutation, who was not eligible for alloSCT, received three different treatments: azacytidine (achieving a partial response), sorafenib plus azacytidine (achieving sustained complete remission for 7 months), and gilteritinib (achieving sustained complete remission for 1 year). The gene discussed is IDH2; the disease is acute myeloid leukemia.