Six of these 10 patients had also acquired new mutations at the time of AML transformation: NRAS (n = 2), FLT3-ITD (n = 2), FLT3-TKD (n = 1), PTPN11 (n = 1), RUNX1 (n = 2), ASXL1 (n = 1), and BCOR (n = 1). This evidence concerns the gene PTPN11 and acute myeloid leukemia.