KRAS and non-small cell lung carcinoma: Smoking-associated KRAS mutations are mainly transversion mutations (G > T and G > C) and are more frequent in females than in males [61,63,64]: In fact, the two most common KRAS mutations in NSCLC are the c.34G > T (p.G12C) and the c.35G > T (p.G12V) changes [65,66], which are more common in females and in current or past smokers [62].