In light of the observation that a group of proteins (A2M, FN1, ALB, PLG, ITIH4, TF, SERPING1, FGA, SERPINA1, FGB, FGG, APOH, APOA1) were involved in platelet activation, signalling and aggregation, we considered that small EVs isolated from ascites could consequently serve as a potential platform for the study of platelet activation, which could provide specific information on the tumour microenvironment, to compare the patients and follow their progress during therapy. The gene discussed is ITIH4; the disease is neoplasm.