Both the groups injected with sEVs (TEM + anti-PD-L1 + sEV) and the group injected with anti-PD-L1 (TEM + anti-PD-L1 + sEV blocked by anti-PD-L1) showed tumor growth recovery compared to the group injected with a combination of TEM and PD-L1 antibodies (Figure 6B). Here, CD274 is linked to neoplasm.