Among the most commonly altered pathways in the sCRC tumours, we observed increased expression of genes involved signalling pathways and cellular processes such as the PI3K-Akt pathway, the interaction with extracellular matrix (ECM) or the apelin pathway (SPP1 and THBS2), the heterochromatin protein formation pathways (SALL4), and other functions related to cell-signalling processes (SRPX2). This evidence concerns the gene APLN and neoplasm.