SPP1 and neoplasm: The tumour-associated genes most strongly overexpressed in CCR primary tumours included those involved in cell adhesion, the extracellular matrix (ECM), and signalling processes (e.g., SPP1 and THBS2), and others associated with tumour cell progression, migration, and angiogenesis (e.g., SRPX2, SPP1, and the pseudogene FER1L4).