Particularly, the signaling of CXCL13 through its receptor, CXCR5, has recently been associated with promalignant intracellular pathways such as PI3K/AKT, MEK/ERK and Rac-GEF/Rac, leading to cell survival, proliferation and migration in different tumor entities [22]. The gene discussed is CXCL13; the disease is neoplasm.