Little has been reported on the role of tenascin C in ccRCC, but a study of prognostic significance based on the correlation of clinical outcomes with histopathological evaluation of tumors from 137 patients showed that patients with tenascin C-positive tumors had a significantly lower survival rate and suggested that they also had increased risk of metastasis [88]. The gene discussed is TNC; the disease is nonpapillary renal cell carcinoma.