Considering KAT6A/KAT6B/BRPF1 were all reported to be translocated or mutated in leukemia [17,59], we further examined hematopoiesis-specific disruption of BRPF1 and found that BRPF1 deficient pups experienced early lethality with acute bone marrow failure due to severe deficiency in hematopoietic stem cells (HSCs) and hematopoietic progenitors in the bone marrow and fetal liver [54]. The gene discussed is BRPF1; the disease is leukemia.