The NEMM domain possesses some sequence similarity to histones H1 and H5, suggesting a regulatory function for this region [32]; the double PHD fingers are capable of recognizing histone H3 tails [33]; the MYST domain catalyzes histone acetylation and interacts with BRPF1 [14,32,34,35]; the acidic region is associated with leukemia and developmental disorders [36,37,38,39]; and the SM domain has transcriptional activation potential [40]. Here, BRPF1 is linked to leukemia.