PSEN2 and melanoma: Expression of AXIN2 (p ≤ 0.0001), NKD1 (p = 0.003), TP53 (p = 0.003), HEY1 (p = 0.03), PSEN2 (p = 0.001), and CUL1 (p = 0.01) was significantly higher in CTNNB1 mutant melanoma, supporting these mutations leading to an over activation of the Wnt pathway.