WEE1 and hepatocellular carcinoma: Huang et al., (2011) [34] studied the role of β1 integrin on the mechanism of lapatinib (a protein kinase inhibitor) resistance in breast cancer and showed that proliferation of both HCC-1954 wild type and HCC-1954TL (resistant to lapatinib and trastuzumab treatment) were inhibited by AIIB2 (a monoclonal antibody that blocked β1 integrin).