Indeed, higher CXCL10 is not only associated with a more severe disease prognosis [9,13,14] but, remarkably, precedes the development of definite SSc, from a preclinical condition of undifferentiated connective tissue disease (UCTD) at risk for SSc, so far referred to as very early diagnosis of systemic sclerosis (VEDOSS) [14,15,16]. Here, CXCL10 is linked to systemic sclerosis.