Patients with type 2 diabetes mellitus (T2DM) also showed significantly elevated serum CML and hs-CRP with a remarkable increase in TLR-4 expression and IL-6 and TNF-α, suggesting that high level of CML is associated with pro-inflammatory cytokines [15]. This evidence concerns the gene IL6 and chronic myelogenous leukemia, BCR-ABL1 positive.