Thus, the decrease in KRAL and the increase in MALAT1 regulate KEAP1 and along with the overexpression of TUG1, NRAL and MIR4435-2HG observed in cancer cells, converge to increase the antioxidant potential of the cell, permitting it to tolerate higher oxidative stress, and once again substantiating the important influence of lncRNA on ROS in cancer. This evidence concerns the gene TUG1 and cancer.