Because the inhibition of tumor angiogenesis that was mediated by the VEGF signaling blockade with bevacizumab correlated with a reversal of VEGFR1 and VEGFR2 protein levels [35], it is highly probable that the under expression of VEGFR2 that was observed in our study may reflect a VEGF modulatory effect, since FGF2 is also capable of modulating the expression of VEGF and its receptors in both an autocrine and a paracrine way [36]. This evidence concerns the gene KDR and neoplasm.