Xiong et al. (2017) also examined the expression of TGF-β, a tissue inhibitor of metalloproteinases 1 (TIMP1), MMP-12, a disintegrin and metalloproteinase domain-containing protein 8 (ADAM8), interleukin-4 receptor subunit alpha (IL4RA), and chemokine (CC motif) ligand 2 (CCL2)—factors that are upregulated in both mouse scl-GvHD and the inflammatory subgroup of SSc patients [136,137,138,139]. The gene discussed is ADAM8; the disease is systemic sclerosis.