Diffuse large B-cell lymphoma (DLBCL)-derived EVs have been shown to differentiate between different subtypes (germinal centre B-cell GCB and activated B-cell ABC) and to express a unique pattern of proteins involved in B-cell receptor (BCR) and ErbB signalling and Fc-gamma-mediated phagocytosis and NK-mediated cytotoxicity [87]. This evidence concerns the gene BCR and diffuse large B-cell lymphoma.