Beyond miRNAs, other EV-derived long noncoding RNAs (lnc-RNA) have been shown to contribute to the generation of a leukaemia-permissive microenvironment, such as EV-circ-0009910, which regulates miR-5195-3p and growth factor receptor-bound protein 10 (GRB10), promoting cell cycle progression [13] and EV-circ-0004136, which promoted AML cell viability, migration and invasion via miR-570-3p, which modulates TSPAN3 expression, allowing an autonomous proliferation of AML cells [14]. Here, GRB10 is linked to acute myeloid leukemia.