Another example of pro-inflammatory potential of HERV-K dUTPase is psoriasis, where HERV-K dUTPase proteins induce the activation of NF-κB through TLR2 to trigger the secretion of TH1 and TH17 cytokines involved in the formation of psoriatic plaques, supporting HERV-K dUTPase as a potential contributor to psoriasis pathophysiology [142]. Here, TLR2 is linked to psoriasis.