With the field of glutamine metabolism becoming a hotspot for research, it has become evident that Gln metabolism plays a prominent role in energy production, biosynthesis, and redox homeostasis, and so is vital for establishing and maintaining a tumorigenic status by becoming involving in cancer-related signaling pathways, such as c-MYC, mTOR, Akt, Ras, and AMPK pathways [23,63,116,117,118,119,120,121]. The gene discussed is MYC; the disease is cancer.