ACE2 and infection: In this respect, cell lines have been useful to elucidate mechanisms of viral invasion and infection [9], allowing the identification of the host receptor Angiotensin-converting enzyme 2 (ACE2), Neuropilin-1 (NRP1) and transmembrane serine proteinase 2 (TMPRSS2) as the main proteins involved in SARS-CoV-2 binding and entry into the host cells [10,11,12,13].