Interestingly, in parallel to the reversal of pathological alterations of NAFLD, the diffuse expression of GNMT was largely restored in HFD-fed mice upon treatment with PGG alone (Figure 2(B3)), metformin alone (Figure 2(B4)) or PGG and metformin combination (Figure 2(B5)). Here, GNMT is linked to metabolic dysfunction-associated steatotic liver disease.