Consistent with the activation of β-CAT, Axin2, a target of Wnt/β-catenin signaling, exhibited a trend toward increase in the infarct area at 4 weeks (p = 0.055, median sham = 0.96 and infarct = 1.76), and significant increase at 8 weeks post-MI (p = 0.03, median sham = 1.02 and infarct = 3.10) in comparison with sham controls (Figure 5G). This evidence concerns the gene AXIN2 and myocardial infarction.