We observed a substantial increase in TNKS1 protein levels at all examined time points (2 weeks, p = 0.006, median sham = 0.94, infarct = 36.63; 4 weeks, p = 0.018, median sham = 0.97, infarct = 12.26; 8 weeks, p = 0.024, median sham = 1.01, infarct = 13.20) (Figure 3D–F), accompanied by a significant increase in TNKS2 at 2 (p = 0.004, median sham = 0.99, infarct = 1.64) and 4 (p = 0.047, median sham = 1.01, infarct = 1.43) weeks post-MI (Figure 3D,E). This evidence concerns the gene TNKS2 and myocardial infarction.