Furthermore, considering the 19 HLA alleles associated with adverse events to the therapy with the highest level of evidence, mention should be made of HLA-B*58:01, which has been shown to have a strong effect on the development of severe cutaneous adverse reactions (SCARs), including Stevens—Johnson syndrome and toxic epidermal necrolysis after treatment with allopurinol, the common treatment for hyperuricemia and gout. Here, HLA-B is linked to hyperuricemia.