BCLC staging is based on three types of prognostic variables: tumor status (number and size of nodes, vascular invasion, extrahepatic spread), liver function (Child–Pugh class, albumin, bilirubin, ascites, portal hypertension), and overall tumor-related health status (Eastern Cooperative Oncology Group (ECOG) classification and presence of symptoms) [63]. This evidence concerns the gene ALB and neoplasm.