Several clinical trials are ongoing to test GPC3-CAR-T cells to treat HCC (NCT04121273, NCT05003895, NCT05155189, NCT05070156, NCT04951141, NCT05103631, NCT03198546, NCT02905188, NCT03884751, NCT03302403) [161]. The gene discussed is GPC3; the disease is hepatocellular carcinoma.