To this end, two authors independently searched for articles in the PubMed database by entering the following keywords in the advanced search builder: melanoma; thyroid disease; (melanoma) and (thyroid disease)/(hypothyroidism)/(hyperthyroidism)/(thyroid cancer)/(thyroid hormones)/(TSH)/(TRH); (melanoma) and (therapy) and (side effects)/(adverse effects). This evidence concerns the gene TRH and melanoma.