It has also been reported that the oral administration of grape-derived polyphenols, composed of catechin and epicatechin in monomeric (~8%), oligomeric (75%), and polymeric forms (~17%), for five months can prevent Aβ oligomerization and attenuate AD-type cognitive impairment in a transgenic mouse model of AD of Tg2576 and APP/PS1 mice [141,142]. The gene discussed is APP; the disease is Alzheimer disease.