In particular, treatment of preclinical PF models (primary IPF fibroblasts and mouse model of bleomycin-induced lung fibrosis) with pan-HDACis results in an attenuation of fibrotic remodelling through the epigenetic rescue of antifibrotic genes and/or the action on fibrosis-related pathways as TGF-β signalling cascade [65]. Here, TGFB1 is linked to idiopathic pulmonary fibrosis.