The activation of CBD might worsen the symptoms as a result of a further increase in TRPV1-mediated CGRP-release, causing the vasodilation of the meningeal vessels, while on the other hand, THC activation of CBR1 may downregulate TRPV1 function and decrease CGRP-release and aid in the relief of migraine pain. Here, TRPV1 is linked to migraine disorder.