CD8A and central nervous system cancer: However, at least in the late stages (day 35), we did not observe any virus replication in the contralateral gliomas (Figure 4) indicating that, at least for brain tumors, the growth reduction we saw for contralateral tumors did not seem to be a result of oncolysis, but might be explained by a kind of “secondary ICD burst“ induced by CD8+ cytotoxic TILs [41].