In glioma, the infection with XVir-N-31 or its offspring XVir-N-31-anti-PD-L1 leads to the induction of ICD in vitro and in vivo, as indicated by the release of the DAMPs HMGB1 and HSP70 or by the surface exposure of the “eat me” protein CRT whereas Ad-WT, expressing E1A13S and E319K proteins that are not present in XVir-N-31 and XVir-N-31-anti-PD-L1 and that are known to possess immunosuppressive functions and counterattack immune recognition, did not [19,28,29]. Here, HMGB1 is linked to central nervous system cancer.