PLG and infection: However, as we were analyzing patients with IRGN, we discovered some IRGN patients with positive NAPlr/plasmin activity staining that were induced by the infections other than Streptococcuspyogenes, such as Streptococcus pneumoniae [77], Aggregatibacter actinomycetemcomitans [78], Mycoplasma pneumoniae [79], and Staphylococcus aureus (both methicillin-sensitive and resistant strains; unpublished case in preparation) (Table 6).