Additionally, CTRP3 enhances the activation of the PI3K/Akt/eNOS pathway, which inhibits endothelial dysfunction induced by oxidized low-density lipoproteins (ox-LDL), thus downregulating an expression of TNF-α, CTRPs, and IL6, postponing atherosclerosis progression [20]. Here, C1QTNF3 is linked to endothelial dysfunction.