C1QTNF3 and obesity due to melanocortin 4 receptor deficiency: CTRP3 influences nuclear factor kappa B (NF-κB) and inhibitory toll-like receptors (TLRs) signaling pathways to reduce the secretion of pro-inflammatory adipocytokines, thus attenuating both obesity-related, chronic, systemic pro-inflammatory responses, and insulin resistance [18,19].