The manipulation of NAD levels, using NAMPT inhibitors (NAMPTi), as described in detail in the next section, can therefore impact also on immune response and this is an important point to be taking in account thinking to the potential use of NAMPT inhibition strategy in cancer therapy, maybe combining NAMPTi to target tumor cells more sensitive with NAD/NAM supplementation to preserve/enhance T cell functions. The gene discussed is NAMPT; the disease is neoplasm.