The most common phenotypic changes that melanoma cells undergo to escape inhibition are linked to epithelial-to-mesenchymal transition (EMT), differentiation/de-differentiation, changes in proliferation rates, and metabolic rewiring, modulating the activity of the master melanocyte transcription factor microphthalmia-associated transcription factor (MITF) and the receptor tyrosine kinase (RTK) AXL [99,100,101], among others. Here, MITF is linked to melanoma.