Functionally, NAMPT, as an intracellular and extracellular factor, impacts on tumor cell biology increasing tumor aggressiveness, correlating with worse prognosis and regulating different processes including metabolic adaptation, DNA repair, gene expression, signaling pathways, cell growth, invasion, stemness, EMT program, metastasis, and angiogenesis [154,155,156,159,170,172,173]. This evidence concerns the gene NAMPT and neoplasm.