Along these lines, recent studies provide evidence that blood biomarkers, including retinol binding protein 4 (RBP-4), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), glial fibrillary acidic protein (GFAP) [55], and adrenomedullin [56], differentiate between ischemic and hemorrhagic strokes with moderate accuracy. This evidence concerns the gene NPPB and hemorrhagic stroke.