CD274 and thyroid gland undifferentiated (anaplastic) carcinoma: On the other hand, in a study by Giannini et al., both anaplastic thyroid cancer and papillary thyroid cancer demonstrated an increase in immune checkpoint inhibitory mediators, including LAG-3, PDL1, PDL2, PD1, T cell immunoglobulin and mucin domain-containing-3 (TIM-3), PVR Cell Adhesion Molecule (PVR) and T cell immunoreceptor with Ig and ITIM domains (TIGIT) [52].