In ovarian cancer LAG-3 and PD-1 on New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1)-specific and -nonspecific CD8+ T cells may be significantly up-regulated by tumor-derived antigen-presenting cells (APCs) or by IL-6 and IL-10 [35]. This evidence concerns the gene CD8A and ovarian carcinoma.